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4-Propyloxy-3,5-dimethoxyphenethylamine (also known as proscaline) is a lesser-known psychedelic substance of the phenethylamine class. It is a structurally related to mescaline and belongs to a series of mescaline analogs that include isoproscaline, escaline and allylescaline. The synthesis of proscaline was first published by David E. Nichols in 1977. Around the same time, Alexander Shulgin sampled and evaluated the chemical at doses up to 60 mg, estimating its potency as five times that of mescaline. Shulgin later documented his findings in the 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").

AN USER EXPERIENCE ABOUT Proscaline:
"... This one is definitely a keeper, but it's going to have to be explored again later this year when the weather is cooler or my hair is shorter or both. I have never experienced a compound that has made me sweat as much as this stuff does. It made me sweat more than MDMA ever had; nor have I ever experienced a compound that made me pee so heavily and frequently. Hydration is key with this stuff, and monitor your electrolyte levels too!

It had a lot of similarities with the 2C series, and if I didn't know better, I'd almost thing it was. It had a lot of the focused clean energy of 2C-I, but held a lot of MDMA/2C-B's entactogenic properties. I'd almost say that this is more entactogenic than MDMA, and probably on par with 5-MeO-MiPT. The body buzz is very persistent through the trip, but everything feels soft.

Music enhancement on this was definitely a tier above other compounds in this class. It is most comparable with 2C-I, 2C-B, or MDMA in the way it affects music, with quite a few LSD-like notes of depth as well, but it never feels deep. My friend noted it as 'if acid and molly had a baby,' which I feel is pretty accurate. I'm sure this stuff hits a lot of the same receptors the same ways as 2C-I, 2C-B, MDA, and MDMA hit, along with some of LSD's receptors; it bares a lot of similarities to those.

Proscaline is SO close to Allylescaline in terms of how it makes me want to lay down ALL THE TIME. The likeness is almost uncanny in that way. Trying this gives me a bit more insight as to what mescaline is like, too. I feel like I want to try escaline before it though, so I have a clearer idea before getting to know the granddaddy of this whole family and what he's about. Would Mescaline make me want to lay down as Proscaline and Allylescaline do? Only time will tell.

This compound is basically what I'd describe as 'mind candy'. It doesn't really hold much substance on its own in terms of a trip, because it doesn't offer much valuable insight or depth. It makes music MUCH better, and it makes things moderately more interesting visually, and my body feels quite buzzy, but that's about as far as it goes. I feel like it would go best alongside a compound than be taken alone, and I feel like LSD would probably be the best candidate for a combination. It lasts too long for a simple night out, making it more ideal for something like a festival, a day at the park, a hike, a museum, or something along those lines. ... "

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Proscaline HCL stock last updated at: December 2024

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