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4-HO-DPT (also known as 4-hydroxy-N,N-dipropyltryptamine and sometimes referred to as Procin) is a psychedelic substance of the tryptamine class. Alexander Shulgin first synthesized 4-HO-DPT and documented it in his book TiHKAL (Tryptamines I Have Known and Loved). It is the 4-hydroxyl analog of DPT. Today it is either used recreationally or as an entheogenic compound.

4-HO-DPT is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-DPT is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains two propyl chains bound to the terminal amine RN of its tryptamine backbone (DPT). 4-HO-DPT is a 4-hydroxy analog of 4-AcO-DPT and the N-substituted dipropyl homolog of psilocin (4-HO-DMT).

Like with most psychedelic tryptamines, 4-HO-DPT is thought to act principally as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 4-HO-DPT's binding efficacy at the 5-HT2A receptors.

AN USER EXPERIENCE ABOUT 4-HO-DPT:
" ... Within seconds at least 3 maybe more 'spirits' came to help me, straight out of the walls. These 'spirits' were humanoid in shape, bright but outlined in shadow. They said, '[name], sit up and breathe...just breathe...we are here with you. We are always with you.'

As I took slow, deep breaths, I closed my eyes and felt a great euphoria and could not help but smile. I opened my eyes and without a word the 'spirits' drifted back into the walls. And my sickness completely passed, I was alive!

With a smile on my face, I cleaned up the trash. Sharps in sharps container. I picked up my phone and as the screen lit up it sent visible energy through my arm and out through the air in the form of a blue lightning patterns.

I found some tunes on my phone, and enjoyed the colors and patterns on my wall. CEV were also very intense and changed to the beat of the music. After listening to music for about 45 minutes I found I could use my legs again and went for a walk around the block right at sunset. Beautiful shades of every color and looked as if the sky was an oil painting. I returned home and made a fire in the fire pit in my backyard and enjoyed the fading visuals.

The overall experience lasted 2.5-3 hours via IV. After the 3 hour mark/20:00 there was a pleasant afterglow effect to everything. I had no trouble sleeping that night. "

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4-HO-DPT stock last updated at: December 2024

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