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4-AcO-DET (4-Acetoxy-N,N-diethyltryptamine, ethacetin) is a lesser-known novel psychedelic substance of the tryptamine class. It is chemically related to psilocin and part of a series of substituted tryptamines that includes 4-AcO-MET and 4-AcO-DMT.

4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains two ethyl chains bound to the terminal amine RN of its tryptamine backbone (DET).

4-AcO-DET is the N-substituted diethyl homolog of 4-HO-DMT (psilocin). 4-AcO-DET is the acetate ester analog of DET and the N-substituted diethyl analog of 4-AcO-DMT. It is a higher homolog of 4-AcO-DMT and 4-AcO-MET.

4-substituted acetylated tryptamines such as 4-AcO-DET, 4-AcO-MET, and 4-AcO-DMT are hypothesized to principally act as a prodrug for their respective hydrolyzed counterparts (e.g. 4-HO-DMT, 4-HO-MET and 4-HO-DET).

Like with most psychedelic tryptamines, 4-AcO-DET is thought to act principally as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 4-AcO-DET's binding efficacy at the 5-HT2A receptors.

In terms of its effects on the physical energy levels of the user, 4-AcO-DET is typically relaxing, stoning and mildly sedating, although it can also sometimes be very stimulating and give users a "wired" feeling. This sense of sedation is often accompanied by uncontrollable yawning.

The "body high" of 4-AcO-DET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.

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4-AcO-DET stock last updated at: November 2024

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