3-Hydroxyphencyclidine (commonly known as 3-HO-PCP) is a novel dissociative substance of the arylcyclohexylamine class that produces potent dissociative, hallucinogenic and
euphoric effects when administered. In addition to its primary activity as a NMDA receptor antagonist, it has been found to have appreciable affinity for the μ-opioid receptor.
3-HO-PCP was first synthesized in 1978 to investigate the structure-activity relationship of Phencyclidine (PCP) derivatives. It was further explored alongside PCP in the 1980s, where
it was discovered to possess μ-opioid agonist activity in animal models. Like other substances of its class, particularly Methoxetamine (MXE), Phencyclidine (PCP), and 3-MeO-PCE, it is
known to primarily induce a state referred to as "dissociative anesthesia", albeit the extent to which this occurs has been reported to be highly dose-dependent and variable in its effects.
AN USER EXPERIENCE ABOUT 3-HO-PCP:
... This was a great experience for me and it really changed my perspective on PCP and its analogues. I can see how this experience could ramp up into something scary if somebody took
too much, but with proper dosing, set and setting, and experience, this substance offers a unique and enjoyable dissociative experience. I was using it in a social setting so I was mainly
just chatting and hanging out with friends, but I could see how solo trips would be very introspective. Definitely will try this substance again, it may be my new favorite dissociative but
only time will tell. Anyone out there who decides to try it themselves, PLEASE be careful. Do not exceed 8-10mg in a 6 hour period or you may experience manic/psychotic effects. Be safe,
be smart, and treat your brain with respect! ...
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3-HO-PCP stock last updated at: November 2024
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